Notably, AMPK also plays a crucial role in preserving respiratory function, as studies in animal models suggest AMPK suppresses TGF--induced proliferation of airway smooth muscle cells and AHR caused by hypoxia-inducible factor/vascular endothelial growth factor (HIF/VEGF) interaction [44, 45]
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Prognostic outcomes are influenced by multiple factors, including tumor size, location, surgical margins, genetic background (particularly NF1 status), and histological grade