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This barrier exists specifically to prevent substances from entering the body

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Presented for research literature review only Wise J (2026)

While these advantages make the model highly useful for in vitro applications, addressing its limitations in future studies will deepen our understanding of neuronal metabolic development and enhance its translational potential

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In addition, we have observed increased neuronal activation in the LH upon OB GLP-1R stimulation and the existence of an anatomical connection between the AON and LH