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Therefore, GIP might increase metabolic flexibility by enabling increased fat utilisation in the fasting state and reducing fat availability in the postprandial state [24 25]

Clinical manifestations of hypothyroidism secondary to Hashimoto's disease include: Fatigue and lethargy Weight gain despite normal appetite Cold intolerance Dry skin and hair loss Constipation Depression and cognitive impairment Bradycardia and elevated cholesterol Diagnosis is established through thyroid function tests showing elevated thyroid-stimulating hormone (TSH) with low free T4 (overt hypothyroidism) or normal free T4 (subclinical hypothyroidism), alongside positive thyroid antibodies

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The multi-pathway approach makes KLOW a valuable research tool for investigating complex regenerative and anti-inflammatory processes in controlled experimental settings