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The screening identified six key pharmacophoric features in the co-crystallized structure of PDE10A (PDB ID: 5UWF) and the ligand 16d, which included one hydrogen bond acceptors (HBA) interacting with Q726, an aromatic ring (AR) represented by the thiophene moiety, and four hydrophobic areas (HA) represented by phenol, sulfide, and fluorine groups

Ethics declarations Ethical Approval Animals handling was done humanely following the guidelines/criteria for managing laboratory animal use and care National Institutes of Health (US) (1986) and recommendations

The rationale behind using vitamin B for hangovers is straightforward: alcohol depletes the bodys stores of B vitamins , and replenishing these nutrients may alleviate some of the discomfort associated with hangovers

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NSAID and antioxidant prevention of Alzheimers disease: lessons from in vitro and animal models