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However, since valproate may interact with these or other concurrently administered AEDs as well as other drugs, periodic plasma concentration determinations of concomitant AEDs are recommended during the early course of therapy [seeDrug Interactions (7)]

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In the presence of OsDHAR, there was a significant increase in CAT enzymatic activity compared to in the presence of LYS or CRY, which were used as negative and positive controls, respectively (Fig