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While beneficial for normal growth, it poses a theoretical risk of accelerating the growth of existing or dormant cancers (for example, prostate, breast, colon) by inhibiting apoptosis (programmed cell death) and driving cell replication

However, its long running time and limited scalability are drawbacks (Table 4) (Sidhom et al., 2020

J., Seo, B., Han, D

With microdosing, the initial dose may be as low as 0.05 milligrams weekly, with a slower increase in the dose than usual. Full doses can range all the way up to 2.4 milligrams per week, depending on the brand and the specific needs of the person being prescribed the medication

Many individuals prescribed these medications may have pre-existing risk factors for reflux, including obesity itself, which is a well-established independent risk factor for GORD

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