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Because tirzepatide activates the GIP receptor in addition to the GLP-1 receptor that semaglutide targets, it produces a broader metabolic effect, including stronger appetite suppression, improved insulin sensitivity, and enhanced fat oxidation

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Recent studies have highlighted the central roles of metabolic regulators AMP-activated protein kinase and Peroxisome proliferator-activated receptor gamma and the histone methyltransferase Enhancer of zeste homolog 2 in modulating corpus luteum function

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mRNA-Laden lipid-nanoparticle-enabled in situ CAR-macrophage engineering for the eradication of multidrug-resistant bacteria in a sepsis mouse model