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It can mean significantly more nausea, vomiting, and GI distress, and in some cases, hypoglycemia in patients who are also managing blood sugar with other medications
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An intra-colonic injection of 180 mmol l 1 propionate (a total dose of ~0.45 mmol) vs saline control (matched for sodium content and pH) in anaesthetised rats resulted in a significant rise in circulating plasma PYY and GLP-1 levels (two-way ANOVA, effect of treatment P =0.024 and P =0.023, respectively)
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Take note, these doses were administered in controlled settings, we recommend speaking with your healthcare provider before adding any new supplements to your diet
Prevention strategy: Include healthy fats at every meal despite appetite suppression
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