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The catalytic activity of the molecule was suggested to be, at least partially, involved (since insulin signaling was improved following inclusion of a DPP-4 inhibitor), but the DPP-4 substrate(s) mediating the effect were not identified

Post-translational regulation Post-translational modification (PTM) PTMs of PRRs and their downstream signaling molecules are critical for modulating their activity and function

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For Wegovy, the dose increases gradually to a maintenance dose of 2.4 mg weekly as tolerated