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"As a neurosurgeon, I have frequently observed the consequences of oxidative stress in traumatic brain injuries, ruptured intracranial aneurysms (widening of blood vessels), and other major insults to the brain," Joseph Maroon, clinical professor of neurological surgery at the University of Pittsburgh Medical Center, Pennsylvania, US, told PTI in an email

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However, effective and alternative therapeutic interventions may be unveiled from a more comprehensive understanding of the biochemical changes mediating ischemic brain injury

Furthermore, loss of NRP1 could compromise the integrity of vascular endothelium, a selective barrier that regulates macromolecular exchange between the blood and tissues

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