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[18] [20] [21] In those taking sulphonylureas, the risk of low blood sugar is increased
Symptoms include itching, skin rashes, swelling, or difficulty breathing
In biochemical assays, an SCF E3 ligase complex containing Fbxo40 directly ubiquitinates IRS1, and this activity is enhanced by increased tyrosine phosphorylation of IRS1
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doi: 10.1038/sj.bjc.6690763 44 HofmannUBWestphalJRZendmanAJBeckerJCRuiterDJvan MuijenGN
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