Fixed-effects models were applied under the assumption of a shared underlying effect size across datasets, while random-effects models accounted for potential heterogeneity among studies
Eligibility criteria We included RCTs with a duration of intervention of at least 12 weeks that compared tirzepatide at a maintenance dose of 5, 10 or 15 mg once-weekly, administered subcutaneously, with placebo or any other glucose-lowering medication
These include temporary skin redness, itch, or irritation after topical application, reported in a small percent of users, single-digit percentages in trials
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Inflammatory markers improved