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Melatonin is truly a pleiotropic hormone: beyond circadian rhythm regulation and sleep, it has notable antioxidant, immunological, and neuroprotective effects all of which have implications for age-related degeneration
The trade-off is twice as many injections
Larger phase 3 trials are needed before clinicians can better understand consistency, durability, and safety in broader groups
If there are no gastrointestinal symptoms, but GLP-1 receptor agonists are not held, proceed with full stomach precautions, or consider evaluating gastric volume by ultrasound
In some cases, a lower-dose approach may be appropriate
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