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Exploratory endpoints were changes in cardiometabolic parameters, use of rescue orforglipron for weight regain of 50% of the weight loss attained in SURMOUNT-5, and changes in patient-reported outcomes
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In May 2026, Lilly reported that its pivotal Phase 3 TRIUMPH-1 trial gave an average weight loss of about 28% to 30% on the top dose
Presented for research literature review only Mikus D et al
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