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Therefore, serum B 12 values above the cut-off point of deficiency do not necessarily confirm adequate B 12 status

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Older adults, vegetarians, vegans, and people with digestive problems that can impede nutrient absorption are at a higher risk of vitamin B12 deficiency and need to supplement

Earlier oral trial METAOD005 randomized 300 adults with obesity to oral AOD-9604 (1, 5, 10, 20, or 30 mg/day) or placebo for 12 weeks

[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy

half-life 3.1 hours