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The fact that GLP-1R agonism can reduce Cyp2e1 levels independent of ethanol intake suggests that GLP-1R agonism may reduce ethanol metabolism and, therefore, result in higher serum ethanol levels
The Kuceki study used a combination protocol
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Conversely in the colonic mucosa, GLP-1 co-localizes with PYY, CCK and the orexigenic Insulin-Like peptide 5 (INSL5) ( L-cells are known to modulate the release of their hormonal cargo in response to the activation of a plethora of receptors capable to sense fats, carbohydrates, proteins and many other compounds
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