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Accessed at wondrhealth.com/blog/5-must-know-myths-about-weight-loss-medications

But this is an off-label use that requires close monitoring

Two available products combine a GLP analog with insulin for once-daily SC injection

When to stay at a dose longer than 4 weeks: You're still losing 1 to 2 pounds per week at the current dose You experienced moderate to severe nausea, vomiting, or diarrhea in the first 2 weeks of the current dose Your provider recommends a slower titration due to age, renal function, or other medications When to increase on schedule: Weight loss has slowed to less than 0.5 pounds per week for 2 consecutive weeks You tolerated the current dose with minimal side effects Your fasting glucose (if diabetic) or HbA1c has plateaued above target When NOT to increase: You're experiencing persistent nausea, vomiting more than twice per week, or signs of dehydration You've had an episode of pancreatitis (current or past) You're planning surgery or a medical procedure in the next 4 weeks (GLP-1 agonists delay gastric emptying, which affects anesthesia risk) The maximum FDA-studied dose is 15 mg weekly

Gastric sleeve may be an option for people who want a more durable weight loss tool and do not want to rely on long-term medication