DSIP addresses both problems: it normalizes evening cortisol and extends the delta-wave recovery window
It was originally isolated in 1977 from the cerebral venous blood of rabbits and has since been found to be present in small amounts in human brains and plasma, with higher concentrations later in the day.3 4 It, or a similar substance, is also present at higher concentrations in human breast milk.5 Because DSIP can cross the blood-brain barrier and is easily absorbed via the gut (unusual for a peptide), some researchers have hypothesized that it may facilitate post-feeding sleep tendencies among newborns, though it remains unclear whether DSIP truly has a hand in neonate sleep-wake cycles.4 5 6 Its mechanism of action is likewise unclear, but it may have something to do with endocrine regulation
Blevins JE, Honeycutt MK, Slattery JD et al (2024) The novel chimeric multi-agonist peptide (GEP44) reduces energy intake and body weight in male and female diet-induced obese mice in a glucagon-like peptide-1 receptor-dependent manner
It neutralizes free radicals and helps to protect cells from oxidative stress, which can contribute to various chronic conditions and signs of aging
Epub 2017 Aug 22
DO THIS INSTEAD: You can increase natural-growth-hormone production by fasting, getting a good nights sleep (growth-hormone levels are highest when you sleep), working out (high-intensity exercise seems to work best), losing excess body fat, and limiting sugar and other refined carbs