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Between Fc5 and -hairpin 2, Q81 J can form a hydrogen bond with the carbonyl group of F358 C3-5B , and several interactions occur between residues T84-Q87 on J chain and N545-R550 on C4-5B including a van der Waals contact between A85 J to V547 C4-5B (Fig

The journey began in the 1980s with research on Gila monster venom, culminating in the discovery of exendin-4, a stable, effective peptide for treating diabetes, demonstrating the progression from initial discovery to blockbuster diabetes medications

TML and GBB are also known as biosynthetic intermediates in l-carnitine synthesis 74

For those who are visual learners, our team breaks down similar lab safety and handling procedures on our YouTube channel, which can help reinforce these sterile techniques

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doi: 10.3389/fphar.2026.1736380 Received 10 November 2025 Revised 20 January 2026 Accepted 21 January 2026 Published 10 February 2026 Volume 17 - 2026 Edited by Madhusudan Prasad Singh, All India Institute of Medical Sciences Raipur, India Reviewed by Hemasri Velmurugan, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), India Prachi Arunima, All India Institute of Medical Sciences Raipur, India Updates Copyright 2026 Wali, Rangraze, Khan, Mufti, El-Tanani and Rizzo