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The Centers for Medicare & Medicaid Services (CMS) is also actively working on prior authorization reforms, with a final rule expected to ease administrative burdens on physicians and save practices an estimated $15 billion over the next decade

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The Phase 2 trial enrolled participants with obesity and evaluated multiple dose levels over 48 weeks: 1 mg dose: 8.7% average body weight reduction 4 mg dose (escalated from 2 mg): 17.1% average body weight reduction 8 mg dose (escalated from 2 mg): 22.8% average body weight reduction 12 mg dose (escalated from 2 mg): 24.2% average body weight reduction Placebo: 2.1% average body weight reduction Those Phase 2 numbers were striking enough

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doi: 10.1016/j.celrep.2020.108626

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