These have a place, but their effect is constrained by one fundamental problem: most peptides dont cross the skin barrier in meaningful amounts
Hot flashes and night sweats can temporarily worsen during rapid fat loss because falling estrogen levels destabilize thermoregulation
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Using this approach, several potential targets have been identified, including PRKACA, NCOA2, and PPARA, which play crucial roles in regulating neuroendocrine function, metabolism, and neuro-immunity [246]