The molecule is very large, making it difficult for the skin to absorb effectively from the surface
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Free heme has also been shown to promote inflammatory gene transcription in macrophages via TLR4 and NLRP3 inflammasome signaling, which have both been implicated in worsened atherosclerosis 72,73,74,75 (Fig
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M., Unciti-Broceta, A., Johansson, E
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