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In normal subjects: GHRH alone: GH secretion of 483.7 GHRP-6 alone: GH secretion of 1434.8 GHRH plus GHRP-6: GH secretion of 3771.5 The combined output is not 1918.5 (the additive sum)

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It binds to ghrelin receptors, triggering short pulses of growth hormone release without significantly impacting cortisol or prolactin levels