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Tirzepatide, sold as Mounjaro for diabetes and Zepbound for weight management, is a dual agonist that engages both the GLP-1 receptor and a second incretin receptor called GIP, or glucose-dependent insulinotropic peptide

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GLP-1s and addiction: lots of promise, but not yet a single robust RCT with a clear clinical outcome

There is now encouraging evidence, as well as recent FDA approvals for specific diabetes drugs, including SGLT-2 inhibitors and GLP-1 agonists, to improve CV outcomes in patients with T2DM

Ipamorelin assists by facilitating nutrient transit and accelerating cellular nutrient utilization