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21 GABA alleviates tic-like behaviors through multiple mechanisms, including restoring neurotransmitter balance, modulating the CSTC (cortico-striatal-thalamic-cortical) circuit, reducing neuronal hyperexcitability, interacting with the gut-brain axis, exerting anti-inflammatory effects, and mitigating stress and anxiety

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21 that utilized a similar crossover design and demonstrated a significantly smaller reduction of mean 17-item Hamilton Depression Rating Scale (HAM-D) scores for a naltrexone-plus-ketamine compared to a placebo-plus-ketamine condition at day 1 postinfusion in individuals with treatment-resistant depression ( n = 12) with a similar effect size ( d = 0.7) to that found in this study ( d = 0.6)

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In addition, DMF increased SCD erythroblasts cystine uptake capability (Fig