Nausea is one of the most frequently reported side effects associated with retatrutide in clinical trials to date, as documented in the Phase 2 randomised controlled trial published in the New England Journal of Medicine in June 2023 (Jastreboff et al., NEJM 2023)
If you're seeing two or more of these, reduce training volume by 3040% for two weeks before making any other changes
In the current study, although none of the participants were on insulin therapy before surgery, the T2D relapse group exhibited higher preoperative HbA1c levels and longer T2D duration, suggesting a more pronounced -cell dysfunction and reduced pancreatic reserve, which may have contributed to the T2D relapse
Macconell L, Pencek R, Li Y, Maggs D, Porter L
It also helps your metabolism work more efficiently, which increases energy and supports weight loss
The FDA briefing documents reflect this pattern of front-loaded side effects that resolve with continued use