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The primary medications to avoid include: Sulphonamide Antibiotics: Sulfamethoxazole (most commonly encountered as co-trimoxazole when combined with trimethoprim) Sulfadiazine (used for toxoplasmosis) Sulfadoxine (combined with pyrimethamine for malaria) Sulfacetamide (topical preparations for eye and skin infections) Co-trimoxazole (Septrin) is commonly used for Pneumocystis jirovecii pneumonia treatment and prophylaxis

A 4-week, randomized, double-blind, placebo-controlled trial showed a significantly improved 24-h blood glucose control [126], and a subsequent pooled post hoc analysis including more than 700 patients provides evidence of the safety and efficacy of a 52 weeks mean follow-up of use of teneligliptin 20 mg daily as monotherapy or in combination with sulfonylurea, glinide, biguanide or -glucosidase inhibitor in Japanese patients with T2DM [127]

Maximum Rybelsus dose is 14 mg daily