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Because of the damage doxorubicin does, it creates large numbers of senescent cells

Tumor cells with mesenchymal phenotype are resistant to the dual IGF-IR/InsR inhibitor linsitinib, due to the decreased expression of IGF2 and InsR, and phosphorylation of IGF-IR/InsR in these cells [182]

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However, the biological plausibility of risk, combined with the lack of long-term human data, demands caution

Hepatology 73 , 968982 (2020)

Tirzepatide tends to produce higher weight loss numbers because it targets two hormone pathways instead of one