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In addition, the negative value of the Z-potential suggests that the GSH carboxylic groups are rather oriented outward

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Such factors must therefore be taken into consideration both during products development stage and after their launch, including: Skin pigmentation: Pulse oximeters function less accurately in patients with higher levels of skin pigmentation (darker skin), resulting in a risk of missing clinically important hypoxia

However, some trace amounts may be detectable longer depending on cumulative exposure