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Ghrelin and glucagon-like peptide 1 concentrations, 24-h satiety, and energy and substrate metabolism during a high-protein diet
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The safety and pharmacodynamic results in the multiple-dose trial must be interpreted in light of the high dose levels (2040 mg oral semaglutide) and the relatively fast initial dose escalation in this trial compared with the phase III trials, where dose levels of 314 mg oral semaglutide are investigated and a slower initial dose escalation is used to minimise gastrointestinal adverse effects
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The recommended dosage of semaglutide for non-diabetic individuals is a gradual increase to 2.4 mg per week, specifically for the purpose of weight management, under healthcare supervision
Figure 2 Statistical Analysis The obtained data concerning the testicular hemodynamics (PSV, EDV, RI, PI, and TAMAX), TE and PH, and biochemical analysis (NOMs and TAC) are presented as means SEM
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