In the tiny human trials so far it is well tolerated, but the sample sizes are small and selective (this isnt a good representation of either a)
These observations allowed postulating that intracellular redox state of the thiol pool, which strongly depends on GSH level, can drive autophagic response at multiple levels (Filomeni et al., 2010)
Like any dreamer, David Sinclair has a tendency to live in the future
In these studies, we have elucidated that RSL3 suppressed PTC spheroid formation, reduced spheroid viability, and these effects were reversed by Fer1 (Fig
Indeed, the wide array of pro-inflammatory cytokines (IL-1, IL-6 and TNF-) released during and after seizures activate inflammatory pathways in neurons and glial cells, and promote BBB leakage, which facilitates inflammatory cell infiltration [3]
Potential Benefits & Side Effects Observations from preclinical and clinical literature