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In the CNS, GSH is synthesized primarily by astrocytes and transported to neurons, where it provides oxidative resistance (Dringen and Arend, 2025)

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In Their Own Words In recent years, GLP-1 receptor agonists like semaglutide (sold under brand names Ozempic and Wegovy) have become revolutionary treatments for obesity and type 2 diabetes, offering substantial weight loss, and myriad other benefits including improved renal and cardiovascular health

GLP-1 drugs are usually optional when following a healthy lifestyle program, but initially can be useful along with other drugs that maybe warranted to help correct / control abnormalities, MD determined

Misuse of peptides can result in severe health issues that outweigh potential benefits

Interestingly, insulin secretion by Cre+ islets is reduced compared to Cre Ex controls, and is further 2-fold less than controls treated with exendin-4 (Cre Ex + )