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This is attributed to its greater hypothalamic activity and extended half-life, which combine for sustained appetite suppression

Furthermore, the clinical heterogeneity of PD, along with the absence of definitive diagnostic biomarkers in early stages, complicates patient stratification and endpoint definition in trials (see details in [15])

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Many patients report reduced snacking, better meal planning, and spontaneous improvements in food choicesselecting protein and vegetables over processed foods

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