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While there is ongoing discussion about the balance and significance of the above mechanisms, it is clear that GLP-1 receptor agonists do reliably trigger weight loss, at least while people are taking the drug
In May 2022, tirzepatide (marketed as Mounjaro) received FDA approval for improving blood sugar control in adults with type 2 diabetes, in combination with diet and exercise
The glucose-dependence that makes them safe, the central action that drives weight loss, the cardiovascular and renal benefits, and the gastrointestinal side effects all trace back to where the receptor sits and how it signals
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