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Current FDA labeling for semaglutide products includes warnings or precautions involving: Acute pancreatitis Acute gallbladder disease Acute kidney injury due to volume depletion Severe gastrointestinal reactions Hypoglycemia when combined with insulin or insulin secretagogues Diabetic retinopathy complications in susceptible patients Serious hypersensitivity reactions Pulmonary aspiration risk during general anesthesia or deep sedation Semaglutide labeling also contains a boxed warning regarding thyroid C-cell tumors observed in rodents
In the technical scheme of the present invention, the purification method in step (6) refers to a conventional purification method in the art, such as HPLC purification method
For patients without a gallbladder, the experience of these side effects may differ in character or intensity due to altered bile flow and fat digestion patterns
A stepwise approach is recommended, guided by clinical assessment and investigation results
Systemic reactions may include gastrointestinal disturbances (nausea, diarrhea, abdominal cramps) when large doses are administered intravenously
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