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Histone acetyltransferase lysine acetyltransferase 2A (KAT2A) enhances tamoxifen resistance by destabilizing p53 and upregulating amplified in breast cancer 1 (AIB1) [82]
Clinical studies have shown that children with ASD have significantly lower levels of GABA in the brain compared to typically developing children, which may be associated with dysfunction of GABAergic interneurons (10)
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The ATTAIN programme positions orforglipron oral GLP-1 therapy as clinically competitive with higher-potency injectables for a meaningful subset of patients
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