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A study by Pickart et al

The circadian system orchestrated by the suprachiasmatic nucleus (SCN) in the hypothalamus and communicated to peripheral tissues primarily through melatonin regulates the timing of virtually every physiological process: hormone secretion patterns, immune cell trafficking, DNA repair enzyme activity, cell division timing, metabolic enzyme expression, and even the blood-brain barriers permeability

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49:54 GLP-1s & Anhedonia Dave and Dr

PMID 26288227

This creates a framework allowing the end user to assess whether or not these compounds align with their individual goals