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MT-II has a cyclic truncated form and acts primarily upon melanocortin receptor 1 (MC1R) and melanocortin receptor 4 (MC4R) , respectively involved in melanogenesis and the regulation of sexual behavior

In animal studies, it has been shown that supplementation with melatonin decreases the risk of pre-eclampsia, preterm birth and intrauterine growth retardation (IUGR)

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To further explore this relationship, we conducted animal studies

Compound 3 (5.0 g, 6.20 mmol) was dissolved in 50 mL MeOH with NaOH (2 g, 50 mmol) under ice bath conditions