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4.2 Key molecular pathways related to ferroptosis-induced neuroinflammation Ferroptosis not only is a consequence of neuroinflammation but also actively propagates the vicious cycle through the release of damage-associated molecular patterns (DAMPs) and glial activation

Trends in Endocrinology and Metabolism (2017) 8

Polyubiquitination of p53 by a ubiquitin ligase activity of p300

Advancements in drug development have led to the discovery of newer, better-tolerated platinum-based drugs with confirmed pro-aging effects [45, 77]

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To directly assess whether MT1 or MT2 mediate melatonins effects in ILC2s, we treated cells with selective MT1 and MT2 agonists and antagonists