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509 Beyond lipid metabolism, AGK acts as a subunit of the TIM22 complex, promoting the import of mitochondrial carrier proteins independently of its kinase activity

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The majority of renoprotective claims derive from rodent models (primarily db/db mice, streptozotocin-induced diabetes, or high-fat diet models), which exhibit fundamental differences from human DKD in gut microbiota composition, metabolic kinetics, and disease progression timelines

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