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Although phase II reactions most commonly follow phase I, not all drugs undergo reactions in that order

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2.7a The Solubility of Ionic Compounds: IonDipole Interactions and Solvation Based on what weve discussed so far, it might seem peculiar that an ionic compound such as sodium methanoate (sodium formate, Na+) dissolves in a polar solvent like water, because doing so eliminates ionion interactions, the strongest of the intermolecular forces

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Not approved by the FDA, EMA, or any regulatory authority for therapeutic use.