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Here are some key trends in GLP-1 indications and the landmark studies behind them: Type 2 Diabetes Mellitus (T2DM): The foundational indication for GLP-1s, with extensive evidence from trials like LEADER (liraglutide), SUSTAIN-6 (semaglutide), and HARMONY Outcomes (albiglutide) demonstrating significant HbA1c reduction and cardiovascular benefits

This may be partly due to genetic defects in detoxification pathways such as MTHFR, COMT, SOD1, SOD2, GSTM1, and various CVT genes

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They are an expensive but practical demonstration that people want better answers