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Un meta-anlisis anterior de pequeos ensayos aleatorios, controlados con placebo haba informado un impacto positivo de la citicolina (1,000 mg/da, administrados durante 28 das a 12 meses) en la memoria y el comportamiento en sujetos con dficits cognitivos asociados con trastornos cerebrovasculares (95)

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The two molecules engage the same receptor and the same downstream branches, so qualitative signaling conclusions often carry over

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Any dysfunction in this chain of events caused by lack of cofactors or mitochondrial dysfunction would lead to reduced ATP formation and increased ROS, Ca 2+ and long chain fatty acid acyls and acylcarnitine buildup

[19] [21] The duration of therapy depends on the indication and patient response