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Studies in rodent models of Alzheimer disease demonstrate that both B-vitamin deficiency and hyperhomocysteinemia can increase levels of the amyloid-forming peptides A-beta 1-40 and A-beta 1-42, increase levels of beta-amyloid plaque, and cause cognitive impairment (190

This activity may be driven by increased levels of brain-derived neurotrophic factor (BDNF) or through a more direct modulation of specific receptors that govern cognitive processes

Transamination of -ketoglutarate gives glutamate

Electrolytes can help support fluid balance, especially sodium, potassium, and magnesium intake