Avoid: grey-market injectable BPC-157 and TB-500 the mechanism is interesting, the human evidence is not there, and the supply chain is unaudited
Cardio alone, without resistance work, does not send strong enough signals to preserve lean tissue during a deficit
It reduces appetite and slows gastric emptying
Dig Dis Sci 69(12):44374445 Anson M, Henney AE, Broadwell N et al (2024) Incidence of new onset type 2 diabetes in adults living with obesity treated with Tirzepatide or semaglutide: real world evidence from an international retrospective cohort study
Therapies based on glucagon-like peptide-1 (GLP-1) reduce rates of cardiovascular and chronic kidney disease in people with type 2 diabetes and/or obesity, with ongoing clinical trials investigating their effects in people with metabolic liver disease, arthritis, and both substance use and neurodegenerative disorders
If tirzepatide stops working for other reasons , that is a different conversation, but heartburn alone is rarely a valid reason for discontinuation