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Side Effects & Safety Per REDEFINE 1 and the Lau (2021) phase 2 program, trial-reported adverse events include: Nausea -- most common (25-40%)
Dosages may require careful adjustment
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Management strategies include starting at the lowest prescribed dose and escalating slowly, taking drops in the morning when the stomach is empty (counterintuitively, an empty stomach often produces less nausea than taking drops after eating), and keeping bland foods available for your first meal after the fasting window
The fact that retatrutide has shown weight loss potentially exceeding both CagriSema and tirzepatide suggests that more receptor targets may indeed produce better outcomes
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