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Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders
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United Kingdom
However, AD pathology extends beyond amyloid and tau, encompassing a multifaceted array of pathophysiological mechanisms, including chronic neuroinflammation, oxidative stress, mitochondrial dysfunction, impaired proteostasis (the homeostasis of protein folding, stability, and degradation), calcium dysregulation, excitotoxicity, and breakdown of the blood-brain barrier (BBB) [16, 17]
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PMID 11468240
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