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The principles of transdermal drug delivery are well-established in pharmaceutical science: The skins barrier function limits the passive diffusion of most compounds Molecules generally need to be below 500 Daltons and have balanced lipid/water solubility properties Therapeutic concentrations of active ingredients must be achievable through the limited surface area of a patch For context, successful medical transdermal patches (like nicotine or hormone delivery systems) utilise compounds selected explicitly for their transdermal permeability characteristics and are developed through extensive pharmaceutical research