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IGF-1 LR3 has minimal direct lipolytic effect compared to growth hormone or beta-agonists, but it supports fat loss indirectly by preserving lean mass during caloric restriction and increasing insulin sensitivity, which shifts substrate utilization toward fat oxidation rather than glucose

As a general rule, IM is favored when the goal is rapid correction of a clinical deficiency, when the patient has difficulty absorbing B12 through oral or sublingual routes, or when a provider wants predictable peak serum levels

Breakfast decisions are already influenced by the drug

Grigoletto Fernandes et al., 2020