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How MariTide Leads to Weight Loss The combination of GLP-1 activation and GIPR antagonism produces several metabolic benefits: Appetite suppression Slower gastric emptying Improved glucose regulation Reduced caloric intake Potential reduction in fat storage Improvements in cardiometabolic markers These effects help people lower their body weight, improve BMI, and enhance overall healthcare outcomes when used as part of a weight management plan

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Chemogenetic activation of Gipr -expressing neurones in either the hypothalamus or hindbrain decreases food intake in mice, suggesting more than one centrally located population of GIPR neurons regulate appetite 7,8